Biologics: A Revolutionary Leap in Medicine
Biologics: A Revolutionary Leap in Medicine
For decades, pharmaceutical research has centred around developing chemical compounds to treat diseases. Scientists in lab coats have meticulously analysed molecules, searching for the next breakthrough. Enter now, a relatively new and exciting frontibioler in medicine – biologics. These innovative treatments are derived from living organisms such as bacteria, yeast, and even plant or animal cells, and they’re transforming the way that we combat diseases, particularly autoimmune diseases such as rheumatoid arthritis. They are also entering the field of vaccination. (1)
Probably the biggest distinction between biologics and other medicines is that biologics are "farmed" or grown, rather than being chemically manufactured. (2) The primary advantage of this field of medicine is their precision. (2) While traditional drugs are more of a general tool, biologics are more like a custom-made key that target specific parts of the body or disease processes. In that sense, they are a kind of “silver bullet”, which makes them very effective for complex conditions that don't respond well to regular treatments. (2) Also, because of their tighter focus, they tend to have fewer side effects. (3)
Vanessa Snow, Head of Medical Affairs at Johnson & Johnson Innovative Medicine, explains the significance of biologics in layman’s terms:
“Think of them as highly specialised proteins, composed of amino acid ‘building blocks’ – similar to how Lego bricks fit together. When introduced into a patient’s body, these biologics target and neutralise imbalances at the molecular level. For example, autoimmune diseases are characterised by an overproduction of certain immune system messengers. A biologic works by blocking these excessive signals, restoring balance and effectively halting disease progression.”
Unlike traditional synthetic drugs, biologics don’t come into to the body as an “external army” but rather, integrate seamlessly with the body’s own processes, like “colleagues”.
“Unlike synthetic drugs, which often act as artificial disruptions to the body, biologics are a natural intervention,”
Snow explains.
“They harness the body’s own healing mechanisms rather than imposing external chemicals. This significantly reduces the risk of rejection or adverse reactions and makes them more effective than many conventional treatments.”
Biologics encompass a broad range of medical advancements, including monoclonal antibodies, immune modulators, gene therapies, vaccines, and therapeutic proteins. (3) Many of these treatments have already proved themselves effective to their traditional counterparts. In fields such as dermatology, for example, biologics have been absolute game-changers. (4)
“We already have biologics that can slow or even halt the progression of diseases such as psoriasis,”
Snow adds.
“While it may not be a cure as such, ongoing treatment provides patients with relief that is equivalent to one.”
“We’ve seen promising results in conditions that have long been considered untreatable,”
says Snow,
“And research continues to expand, unlocking new possibilities across medical fields, from oncology to neurology. We’re on the brink of a medical revolution,”
References:
1) WHO. Biologicals. Accessed here: https://www.who.int/health-topics/biologicals#tab=tab_1
2) MDPI. Green Biologics: Harnessing the Power of Plants to Produce Pharmaceuticals. Accessed here: https://www.mdpi.com/1422-0067/24/24/17575
3) Cleveland Clinic. Biologics (Biologic Medicine). Accessed here: https://my.clevelandclinic.org/health/treatments/biologics-biologic-medicine
4) IQVIA. BIOLOGICS – THE KEY TO NEXT GENERATION DERMATOLOGY R&D? Accessed here: https://www.iqvia.com/-/media/iqvia/pdfs/library/white-papers/biologics-the-key-to-next-generation-dermatology-rd.pdf
